Question:
no it isn’t directly related to PTSD…moreso migraines, as I get them a lot. The drug is called Amitripyline which is really an antidepressant. My dose is one 25mg tablet a day at HS (hour of sleep)…which appears to be a small amount compared to others who seem to need 150mgs a day for the depression part of it. Anyways- I took the first pill yesterday at about 2:30pm (as I work nights and don’t really have a set schedule for taking HS meds). Anyhow-I’d say around 4:30pm I was out cold and didn’t wake up until 6:30 this morning. I know it’s going to take time for my system to adjust, I just hope it adjusts quickly…as I feel like doing things but yet do not feel like doing anything. Along with migraines I’m hoping this medication will help with irritableness as well as anxiety. Which is why my PCP went this way ALONG with Imitrex (sp). Wish me luck lol.. Paula-who is hoping weight gain is not a side effect for me!!
Response:
Paula, sorry to be reading the posts backwards (it’s where my head has been today). Read in the literature that the new med I’m on, Nefazodone, is also used to treat migraines and persistent headaches. My med knocked the hell out of me also which was a surprise (I’ve been taking different combinations of meds for over 10 years now). I agree with you, I hope that my body gets used to it ’cause I won’t be driving a car until I do. Larry L. "PAdams4232" <padams4…@aol.comNo2Spam> wrote in message
news:20010927115915.08542.00000936@mb-fg.aol.com… – Hide quoted text — Show quoted text -> no it isn’t directly related to PTSD…moreso migraines, as I get them a lot. > The drug is called Amitripyline which is really an antidepressant. My dose is > one 25mg tablet a day at HS (hour of sleep)…which appears to be a small > amount compared to others who seem to need 150mgs a day for the depression part > of it. Anyways- I took the first pill yesterday at about 2:30pm (as I work > nights and don’t really have a set schedule for taking HS meds). Anyhow-I’d say > around 4:30pm I was out cold and didn’t wake up until 6:30 this morning. > I know it’s going to take time for my system to adjust, I just hope it adjusts > quickly…as I feel like doing things but yet do not feel like doing anything. > Along with migraines I’m hoping this medication will help with irritableness as > well as anxiety. Which is why my PCP went this way ALONG with Imitrex (sp). > Wish me luck lol.. > Paula-who is hoping weight gain is not a side effect for me!!
Response:
"Lawrence Lusk" <lelvn…@charter.net> wrote in message
news:tr7chtjgptfmc8@corp.supernews.com… > Paula, sorry to be reading the posts backwards (it’s where my head has been > today). Read in the literature that the new med I’m on, Nefazodone, is also > used to treat migraines and persistent headaches. My med knocked the hell > out of me also which was a surprise (I’ve been taking different combinations > of meds for over 10 years now). I agree with you, I hope that my body gets > used to it ’cause I won’t be driving a car until I do. > Larry L.
Hi Larry. Feels weird to be talking to Larry, fer some reason. 
Nefazodone is a potent blocker of the liver enzyme 2D6. This enzyme is a very important one, as it is part of the detoxification process of a lot of different chemicals, including tylenol, opiates, ketoprofen…. And by some quirk of genetics, there’s a huge variability between people in how effectively their 2D6 works in the first place, over a 100-fold variability. There’s a huge possibility of med interactions with nefazodone. You could be having a toxic reaction to the med itself. I was on that stuff, and it made me progressively stupider and stupider. I lost the ability to think clearly, memory nearly missing, and balance problems. One day I was walking down the street and I couldn’t avoid walking into a telephone pole. I stopped taking it. I don’t know how I retained enough sense to know that it was the problem, but I just quit. Later, I looked it up on Medline and other medical info sites, and gave my doctor the heads up. He had not known of the 2D6 effect, and he very quickly realized that he had other patients whose problems were attributable to this med. If you seem to be getting worse over time, give serious thought to this, OK? Regards, Larry
Response:
Thanks Larry, nothing in the lit that I’ve found so far (will look harder now) that mentioned 2D6, D4 and D5 yes but those seemed to be pluses. I’ll be very careful but I’ve also got to find something that works consistently. Constantly being sleep deprived is driving me nuts (if that’s still possible). Paula might want to do some checking on her med also. I don’t trust the Pdocs to be up on their reading like I used to (was a mistaken trust then I suspect also). Larry L. "Larry Hoover" <larryhoo…@sympatico.ca> wrote in message
news:tkPs7.22839$Df4.2485282@news20.bellglobal.com… – Hide quoted text — Show quoted text -> Hi Larry. Feels weird to be talking to Larry, fer some reason. > Nefazodone is a potent blocker of the liver enzyme 2D6. This enzyme is a > very important one, as it is part of the detoxification process of a lot of > different chemicals, including tylenol, opiates, ketoprofen…. And by some > quirk of genetics, there’s a huge variability between people in how > effectively their 2D6 works in the first place, over a 100-fold variability. > There’s a huge possibility of med interactions with nefazodone. > You could be having a toxic reaction to the med itself. I was on that stuff, > and it made me progressively stupider and stupider. I lost the ability to > think clearly, memory nearly missing, and balance problems. One day I was > walking down the street and I couldn’t avoid walking into a telephone pole. > I stopped taking it. I don’t know how I retained enough sense to know that > it was the problem, but I just quit. > Later, I looked it up on Medline and other medical info sites, and gave my > doctor the heads up. He had not known of the 2D6 effect, and he very quickly > realized that he had other patients whose problems were attributable to this > med. > If you seem to be getting worse over time, give serious thought to this, OK? > Regards, > Larry
Response:
"Lawrence Lusk" <lelvn…@charter.net> wrote in message
news:tr7hopaaitiea7@corp.supernews.com… > Thanks Larry, nothing in the lit that I’ve found so far (will look harder > now) that mentioned 2D6, D4 and D5 yes but those seemed to be pluses. I’ll > be very careful but I’ve also got to find something that works consistently. > Constantly being sleep deprived is driving me nuts (if that’s still > possible). Paula might want to do some checking on her med also. I don’t > trust the Pdocs to be up on their reading like I used to (was a mistaken > trust then I suspect also). > Larry L.
I should have checked the lit before I posted….nefazodone is only a weak inhibitor of liver enzyme 2D6. It is 3A4 that it blocks. What I said about interactions remains true, but I had the wrong enzyme in my brain (i’m personally very low functioning in 2D6). Losing 3A4 along with weak 2D6 activity is not cool. The easiest way to find out what drugs you should not take with nefazodone is to do a search on drug interactions with the antifungal ketoconazole, which is a potent inhibitor of 3A4. Larry
Response:
Have you tried Imigran or Zomig for your migraines??? Shane "PAdams4232" <padams4…@aol.comNo2Spam> wrote in message
news:20010927115915.08542.00000936@mb-fg.aol.com… – Hide quoted text — Show quoted text -> no it isn’t directly related to PTSD…moreso migraines, as I get them a lot. > The drug is called Amitripyline which is really an antidepressant. My dose is > one 25mg tablet a day at HS (hour of sleep)…which appears to be a small > amount compared to others who seem to need 150mgs a day for the depression part > of it. Anyways- I took the first pill yesterday at about 2:30pm (as I work > nights and don’t really have a set schedule for taking HS meds). Anyhow-I’d say > around 4:30pm I was out cold and didn’t wake up until 6:30 this morning. > I know it’s going to take time for my system to adjust, I just hope it adjusts > quickly…as I feel like doing things but yet do not feel like doing anything. > Along with migraines I’m hoping this medication will help with irritableness as > well as anxiety. Which is why my PCP went this way ALONG with Imitrex (sp). > Wish me luck lol.. > Paula-who is hoping weight gain is not a side effect for me!!
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